Transmission geometry

The data on the right were taken with the IµS on a D8 diffractometer in transmission geometry. The measurement was recorded with a "Quazar" Montel optic that focused the beam onto the area detector. The sample was LaB6 powder, and the distance between sample and detector was 29.2 cm, the data collection time was 60 sec. In this configuration we obtained a resolution of 0.08 deg, an excellent resolution for a measurement with an area detector, close to the resolution typical of a Bragg Brentano diffractometer.

 

 

X-ray through the tablet!

Using the same setup, we measured the x-ray diffraction transmitted through an ibuprofen pill. The left measurement shows comparing data obtained with a conventional sealed tube setup. With the IµS system we have obtained 10 times more intensity in 8 times shorter time! This is 80 times faster than before even though only a section of the area pattern was integrated. Also, the spotiness of the pattern is also much smaller when measured with the IµS, because a larger sample area was exposed.

Ibuprofen, measured in transmission with sealed tube (left) and IµS and VÅNTEC-2000 (right)

In this way it is possible to characterize materials such as pharmaceuticals in seconds or faster. The data shown below were obtained from two ibuprofen tablets from two different pharmacies. The x-ray diffraction pattern reveals that one of the tablets contains significant amounts of beta lactose in addition to ibuprofen.

Comparison of whole Ibuprofen tablets from two pharmacies
black - Ibuprofen tablet, sample 1
blue - Ibuprofen tablet, sample 2
red - Ibuprofen C13H18O2
green - β-Lactose C12H2
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